Throughout history many people have stumbled upon a discovery accidentally. Some examples of these accidental discoveries occur when someone is working on an experiment and it results in a completely different outcome then expected. No matter how these discoveries were made, there has been several significant discoveries that happened accidentally in history. These accidental discoveries may produce a physical product, but it also allows people to keep an open mind in their experiments, not knowing what the outcome may be. It is interesting to look at these accidental discoveries and see how one experiment can turn into something completely different. In this anthology, you will find a collection of examples of accidental discoveries. These examples were selected because we believe they have had a significant impact in the world.
Continue reading “Scientific Anthology: Accidental Discoveries”
They continue to maintain that Henry Erlich’s work in making PCR into what is probably one of the most useful–and widely used– biochemical tools, the genetic equivalent of a photocopying machine, has been under-credited. But Mullis emphatically disagrees: ‘Henry Erlich? He was just the lucky person in the lab down the corridor who got to use PCR to amplify stuff’ – Weinberg, p157
I found this argument between Erlich and Mullis very interesting, mostly because I do not see how Erlich in any way would share in the Nobel Prize. Also, it seems to be a unique case to begin with because not many industry scientists receive Nobel Prizes. But regardless, I agree with Mullis solely getting the recognition. It is true that his company gave him the platform on which he needed to fully implement his idea, the “slow hunch” (Steven Johnson) was entirely his. In order for Mullis to find his eureka moment in that car that day, he needed to have a problem to solve and mull over in his head (which he did). Erlich’s contribution was patented fairly, as it was used directly to make money for his company.
Erlich developed PCR technology and made it practical, but he had no say or contribution to the actual theory or idea of what PCR was and how it worked. In Steven Johnson’s terms, he simply built off the platform. It would be like the fish who built its home on a coral reef taking credit for the reef, or the animal that feeds and thrives on the habitation surrounding the reef ecosystem, taking credit for its food being there to begin with, effectively sharing the credit with the polyp skeletons. The only action that is attributed to this feeding animal is that of eating and thriving. This is similar to Erlich, he took a base and built and thrived upon it.
“Miraculously, everything then fell into shape. Crick saw it and no matter how hard he tried, could not come up with a reason why it should not be the solution.
‘From the start we hoped for some chemical revelation that would lead to the correct structure,’ Waston wrote. ‘But we never anticipated that the answer would come so suddenly in one swoop and with such finality.
It was a true Eureka moment.” -Weinberg, pg 38-39
This section grabbed my attention immediately. After reading Johnson’s book, we learned that true ‘Eureka moments’ are much rarer than they’re made out to be. Watson and Crick are portrayed as almost overconfident in their intelligence and their abilities; it’s understandable that Watson wanted it to seem as though the answer to their DNA problem came to them so quickly.
But if we look at the rest of the chapter, we can see that their discovery wasn’t really a Eureka moment after all. Like many good ideas, it was a matter of finding and combining all the right pieces, such as the work of their colleagues before them. It was in part because of a hunch that Watson and Crick had, the idea that DNA was likely a helix structure.
The revelation that DNA is a double helix did not come to Watson and Crick all at once; it was a problem that both of them thought about for a long time, gathering bits and pieces of information that would eventually come together and lead them to the answer.
” ‘From the start we hoped for some chemical revelation that would lead to the correct structure’, Watson wrote. ‘But we never anticipated that the answer would come so suddenly in one swoop and with such finality’. It was a true Eureka moment” (Weinberg 38-39).
I think that this quote, about Watson and Crick’s discovery of the structure of DNA, illustrates Steven Johnson’s point about slow hunches being the basis of all good ideas. There actually aren’t generally such things as “eureka” moments. True, it seemed as if Watson just miraculously stumbled upon the answer to DNA’s structure, but in reality his process was different. For one, he collaborated the whole time with Crick, and so his ideas were inevitably influenced by and checked by someone else.
For another thing, Watson and Crick were basically at a stumped point in their research when they went and saw Rosalin Franklin’s work of X-ray photographs of DNA. Weinberg even says that with “more earnest manipulation of their models” (Weinberg 38), they started working harder to find the solution. This basically means that competition was a driving point to them making their discovery.
Finally, the two scientists were trying the whole time to answer one question: what was the structure of DNA? They were searching for this specific answer. They had exhausted basically all other possibilities and answers when they made the discovery. From this, one could argue that they just naturally arrived at the answer from their slow hunch.
“In a sense, dreams are the mind’s primordial soup: the medium that facilitates the serendipitous collisions of creative insight. And hunches are like those early carbon atoms, seeking out new connections to help them build new chains and rings of innovation.” -Johnson, pg 102
I thought this passage was really cool, because it connects a lot of previous ideas discussed in the book: the liquid network and hunches and carbon atoms. And I think what’s interesting about dreams is that they can sort of provide a spark for all these eureka moments we’ve talked about. We’ve talked about how these eureka moments don’t just come out of nowhere; there has to be a background, a collection of unconnected ideas that maybe you’ve been thinking about for a while, and the eureka moment is when you figure out which pieces fit together. And dreams sort of play around with our memories (the pieces we have on the table), putting them together in ways our conscious minds just wouldn’t think to do. The pieces have to be there to begin with, and sometimes it takes serendipity and the random connections of dreams to figure out new ways to put the pieces together.